Understand what is loaded
WordPress loads and caches autoloaded options for use during requests. A large set of options can increase database work and memory use, but the Site Health warning is a starting point, not proof that every option is unnecessary.
Record the WordPress version, object-cache configuration, Site Health result and a representative request baseline. Autoload values and APIs can vary across versions, so use version-appropriate WordPress documentation and tools.
Identify owners before changing data
On a backed-up staging database, inspect the largest autoloaded values and map each option to its plugin, theme or core component. Large serialized values must remain valid; editing or deleting them without understanding their owner can break settings or application behavior.
Compare the size and access pattern with profiling evidence. A frequently used option may be large for a legitimate reason. A removed plugin may leave data behind, but confirm it is no longer needed and that a recovery copy exists before cleanup.
Make a supported change
Prefer the owning component's supported cleanup or configuration procedure. Where an autoload setting must change, use an appropriate WordPress API for the installed version so caches remain consistent. Do not run a blanket query that disables autoload for all options.
Retest the affected plugin and theme workflows, compare request timing and memory with the same baseline, and check logs for missing settings. Plan a production change with a restore path and verify the result after caches have been handled according to the site's architecture.
Further reading
Read the official documentation. For help applying these checks, explore Clouvenix services.